What is Endometrial PRP?
Endometrial Platelet-Rich Plasma (PRP) therapy is an advanced regenerative treatment designed to improve the thickness and receptivity of the uterine lining (endometrium). During the procedure, concentrated growth factors derived from the patient's own blood sample are gently infused into the uterine cavity. This technique is often recommended for women with a persistently thin endometrium or those who have experienced repeated implantation failure during IVF cycles, as it aims to create a healthier, more vascularized environment for embryo implantation.
PRP stands for Platelet-Rich-Plasma. Plasma. PRP is plasma fraction of autologous (own) blood with the concentration of platelets 4-5 times above normal. Platelets are tiny blood cells that are responsible for clotting of blood, growth as well as tissue healing and regeneration.
How is PRP Therapy used in Infertility Patients?
Overview
PRP Therapy has been recently tried in the following areas
- Persistently Thin Endometrium: Enhances the Endometrial Thickness
- Addressing Recurrent Implantation Failure (Recurrent Pregnancy Loss)
- Premature Ovarian Failure: Improves Ovarian Reserve
Frequently Asked Questions About Endometrial PRP
Find answers to common questions about endometrial PRP therapy, procedure steps, safety, and benefits.
Endometrial PRP (Platelet-Rich Plasma) is a regenerative treatment where concentrated growth factors from your own blood are infused into the uterus to improve lining thickness and receptivity.
It is recommended for women with a persistently thin endometrium who do not respond to standard medications, or those with a history of recurrent implantation failure during IVF.
No, the procedure is quick, minimally invasive, and generally painless, requiring no anesthesia. It feels similar to a routine speculum examination or IUI.
A small sample of your blood is drawn and placed into a centrifuge machine, which spins rapidly to separate and concentrate the platelets and growth factors.
PRP is typically performed a few days before the expected embryo transfer window or during the estrogen preparation phase of a frozen embryo transfer cycle.
Because PRP is autologous (derived from your own blood), the risk of allergic reactions, rejection, or transmission of blood-borne diseases is virtually nonexistent.
Follow-up transvaginal ultrasound scans are usually scheduled 3 to 5 days after the infusion to evaluate the regenerative response and measure thickness.
Most patients undergo a single infusion per cycle, though your fertility specialist may recommend a second session depending on how the endometrium responds.
While PRP significantly improves uterine receptivity and lining thickness in responsive patients, it enhances success chances rather than guaranteeing a live birth.
Yes, PRP is most commonly integrated as an add-on therapy during FET cycles to optimize the uterine environment before thawing and transferring the embryo.
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