Known Parental Rearrangement
A parent has a balanced translocation, inversion or another rearrangement with a risk of unbalanced embryos.
What Is PGT-SR?
Preimplantation genetic testing for structural rearrangements checks IVF embryos for chromosome imbalances linked to a parent's rearrangement. It can help avoid transferring an embryo with missing or extra chromosome material. Parental karyotyping and genetic counselling guide the test. By precisely screening blastocysts for unbalanced translocations, inversions, or deletions, PGT-SR helps select chromosomally balanced embryos prior to transfer. This specialized testing aims to significantly lower the risk of recurrent miscarriages and genetic conditions associated with structural chromosome variations, guiding a safer path to a successful pregnancy.
A Family-Specific Decision
When Is PGT-SR Suggested?
Repeated Pregnancy Loss
Consider parental chromosome testing when the history or pregnancy results suggest a structural cause.
An Affected Pregnancy or Child
A chromosome imbalance in a child or pregnancy may prompt parental karyotyping.
Infertility with a Genetic Finding
A structural chromosome finding may help explain reproductive difficulties and guide IVF planning.
What PGT-SR Cannot Guarantee
Your Safety
Care throughout your treatment
What PGT-SR Cannot Guarantee
A cycle may produce no suitable embryo. Age, ovarian reserve and embryo development affect the opportunity.
Testing reduces a specific genetic risk. It does not remove all pregnancy risks or detect every genetic condition.
Biopsy samples only some cells. Technical error, mosaicism and test resolution can affect the result.
Offer diagnostic confirmation in pregnancy. CVS or amniocentesis is discussed; NIPT is not equivalent.
PGT-SR Cost
What Costs Should We Ask About?
Request costs for work-up, IVF, biopsy, testing, freezing, storage and transfer, including repeat or inconclusive testing.
01
Parental karyotyping and laboratory feasibility review.
02
Stimulation, egg collection and embryo culture.
03
Blastocyst biopsy and PGT-SR analysis.
04
Vitrification, storage and frozen embryo transfer.
Important to know
Include repeat or inconclusive testing in the estimate.
Quick Reference
Discuss your chromosome report with a specialist.
PGT-SR FAQs
Your Chromosome Testing Questions
Yes. Many carriers have no health problems, yet may form eggs or sperm with an unbalanced chromosome complement.
The parental karyotype identifies the rearrangement. Its exact details help the laboratory assess test feasibility.
No. Risk varies with rearrangement type, breakpoints and carrier sex. Sperm study figures cannot be applied to eggs.
No. PGT-SR targets a structural rearrangement. PGT-A assesses chromosome number; coverage and reporting may overlap.
No. It tests embryos to guide selection. It cannot change an embryo's chromosome structure.
Standard copy-number testing often combines normal and balanced results. Ask if specialised testing is feasible.
Bring both partners' karyotypes, any child or pregnancy genetic reports, miscarriage records and previous IVF details.
Request costs for work-up, IVF, biopsy, testing, freezing, storage and transfer, including repeat or inconclusive testing.
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